Since 1985, Prof. Buah-Bassuah has served University of Cape Coast  in Ghana by rising to full professor and headed various departments, faculties, directorates and fulfilling National and International assignments. He has delved into lasers and its applications in Physics as  applied to industry, environment, agriculture and biomedicine. He has conducted detail studies into liquid-drop fragmentation in miscible fluids dynamics leading to fractilisation which has relevance to the infusion processes in medicine. He has also formulated and constructed LED/Laser Diode Fluorometer for chlorophyll evaluation, and pre/post-harvest fruit selection. He has also set up an environmental air-pollution monitoring station using  an optical equipment at Tema Oil Refinery, Tema, Ghana for climate monitoring in the region. He has used lasers for industrial applications for alpha track analysis, automatic inspection of roads and Infra Red holographic measurements of surfaces and 3-D objects. He has supervised 25 M.Phil and 10 Ph.D. students with ICTP, TWAS Grants and IPPS Uppsala University projects.

His rich leadership qualities has helped to promote optics and photonics in the African region through the formation of optical related societies to educate the young ones and established Laser Centre in his University. He has served on several National Boards to promote science and technology. He was the expert of Ghana-UNESCO Commission delegation to propose and proclaim the International Year of Light and Light-based Technologies at UNESCO and its subsequent  annual celebration. Presently, he is Chairman, Ethics Review Board of The, University of Cape Coast, Ghana and  Council Member, Council For Scientific and Industrial Research, CSIR , Ghana.

His pioneering role in lasers, Optics and Photonics in the formation of LAMNetwork in Dakar, Senegal, in 1991, set up Ghana-West Africa International Commission of Optics and a founding member of African Laser Centre (ALC) in South Africa, and Optics Within the Life Sciences, OWLS in Africa enabled him to be awarded Fellow of SPIE (USA), Fellow of AAS in 2017 and Ghana Academy of Arts and Sciences (GAAS) (2011) and was made an International Council member of Optical Society of America (OSA).The University of Cape Coast at its 50th Anniversary honoured him with prize of innovation and creativity.

He is a reviewer to some UK scientific journals, attended over 105 conferences showing scholarship and has over 80 articles in indexed journals and edited four conference proceedings books. His expertise in laser Physics enabled him to share his experiences in short visits for research collaboration with Cheikh Anta Diop University, Dakar, Senegal, Stellenbosch University, South Africa, National University of Science and Technology, Bulawayo, Zimbabwe, University of Addis Ababa, Ethiopia and Non-Linear Optics Institute at Nice ,France. He has been External Examiner to Universities in Ghana and other African Countries.  He is a renowned researcher and distinguished scholar.