Richard Amewu
Country (Nationality)
Ghana
Grantee Title
Project: Medicinal chemistry progression of MMV696444 identified from the MMV Pathogen Box for malaria and tuberculosis
Grantee Description
Dr Richard Amewu is a Senior Lecturer at the Department of Chemistry at University of Ghana and has since established a maiden Drug Discovery group focusing on synthesis of small molecules. Richard is a Medicinal Chemist with interest in the development of novel therapeutic agents for neglected diseases. He is a synthetic organic chemist with special interest in drug-design, chemical biology and medicinal chemistry of antimalarial, antimycobacterial, and anticancer drugs as well as neglected diseases.
Richard had both his MSc and PhD at University of Liverpool and played major roles in several projects in the Liverpool Drug Discovery group. Research undertaken by Richard resulted in 4 patents and 25 high impact peer reviewed publications with two drug candidates selected for evaluation as potential malaria drugs.
Project: Medicinal chemistry progression of MMV696444 identified from the MMV Pathogen Box for malaria and tuberculosis
This project seeks to continue medicinal chemistry efforts on MMV696444 scaffold from the MMV Pathogen box. Novel compounds shall be designed and synthesized for microbial/parasite and ADME screening in order to establish any Structural Activity Relationships (SAR) and structure property relation (SPR) profile and to discover an early lead with in vivo antitubercular/antimalarial activity as a proof-of-concept.